Guile
You both play Guile. This should be a cakewalk.
Ryu
Ryu is all around, which means he has all weaknesses. Take advantage of this by using any strategy you can think of.
Ken
Guile's brother in law is no pushover. You can beat Ken by reminding him to go home and be a family man.
Chun-Li
It's not ok to hit women. Let Chun-Li win.
Cammy
Like above, it's not ok to hit women. Lucky for you, Sonic Boom isn't a punch. You should be able to keep her out with literally that and Flash Kick, which is OK, because it is also not a punch.
Zangief
After the results of the 2016 election, Russia is officially a part of the USA. If you let Zangief win this match, you will recieve a vodka, 1000 ruble, an autographed photo of Donald Trump, and a thank you letter from Vladamir Putin.
Dhalsim
Dhalsim players all use drugs. Bring out a lot of food, and they'll get munchies. This distraction will make it impossible for them to beat you.
Vega
Has science gone too far? American street fighter figures out how to grab spanish ninjas in the air with one secret trick!
M. Bison
Bison: "You have made me a happy man"
Guile: "Next I make you dead one"
Nash
Honestly, I don't know who this is. People tell me it's Charlie, but Charlie is a green monster lol.
I will update this guide when we know his identity, but until now, fight him like he's Frankenstein.
R. Mika
You aren't allowed to punch women, but technically you aren't supposed to punch anyone in wrestling. Take a page out of Brock Lesnar's playbook, and suplex R. Mika over and over again.
Birdie
Birdie against Air Force pilot? This speaks for itself.
Karin
One thing is for certain: Karin has absolutely zero moves that go over or through your fireballs, and you should probubly throw them without thinking of any possible counter-strategies.
Laura
Sean's sister right? Not a threat.
FANG
FANG players like to equip the "Viral Heart Disease" capsule. Make sure you use the "vaccine" capsule against him.
Rashid
What is this, Dragon Ball Fighterz? Rashid's scouter must be defective, because if he could see Guile's power level, he'd be shaking. Easy fight.
Necalli
Do not underestimate Necalli. All Necalli players are jerks who hold back until the end of the fight in which they use his Super Sayian 3 transformation. Maybe use the "Yakon" capsule?
Alex
You're a more experienced soldier, so use your advance millitary tactics, like spamming Sonic Boom, and the most deadly millitary art, the suplex.
Ibuki
Make sure to block low, as Ibuki's neck breaker slide move is really annoying. Use crouch tech option selelct on wakeup against her vortex. If things get really bad, use wakeup Ultra 1 and hope for the best.
Balrog
Use a kick. It will confuse Balrog so much that he'll give up.
Juri
This is a hard fight, as Juri's zoning game has only gotten better since the SF4 series, and she's got great normals to play footsies with. On top of that, you can't punch her because she's a girl, but her kicks are better than yours. I'd say try the Handcuffs, but she might like that. Impossible.
Urien
In previous Street Fighter games Urien was a hard matchup for Guile, but he has one weakness: Aegis Booster. Aegis Booster is a big purple shield that boosts the strength of all fireballs that go through it. If you see this move, throw as many Sonic Booms as you possibly can at it.
Akuma
Akuma is made of paper. Sonic Blade is kinda like scissors, but made of lasers, so you should be able to cut him in half easy. Watch out for his hug of death move.
Kolin
This lady stole your crouching roundhouse. Prove that yours is better by only using sweep. Her jump is hella fast, and you'll never be able to anti-air it, so be careful.
Ed
You've got a better theme song, so there's no way you can lose.
Abagail
I've never seen anyone pick her, so I can't give any advice on this one.
Menat
Throw Sonic Boom at her over and over, because that works against everyone. This is Guile's best matchup!
Zeku
Zeku is not so strong. Most Zeku players are cheaters though, who have hacked the game to replace him with Strider Hyriu from Marvel Vs. Capcom. Can't beat a cheater, so just take the loss and report them.
Sakura
Watch out for Sakura's amazing normals. The only normal she has that's bad is C.MK. Don't worry about that one, but watch out for some of those nasty moves like D/F HK. That one has a huge hitbox!
Blanka
Carlos Blanka makes his grand return to Street Fighter! Best choice in this matchup is to make sure you're on the "Bison's Lair" stage, and press Start so that a big picture of Guile from the movie covers all of the monitors. It will distract them and you'll win easy.
Falke
This character is OP. Why did they give Cammy a stick. That's not fair. This is Street Fighter, not Street Sticker!
Cody
Whatever political party you like, Cody is a member of the opposite party, which means he's a threat to America that has to be stopped!
G
You're an American, it's your duty to protect the president, not fight him!
Sagat
The only joke is how terrible Sagat is in this game.
Kage
This isn't Virtua Fighter, so you'll be fine.
Poison
Pretty much a mirror matchup. Both have handcuffs. Rely on your spacing and hope for the best.
Lucia
I dunno, don't get hit by Ein Trigger? I got nothing.
E. Honda
There's really no reason to actually explain this matchup. If you've played it, you know exactly what to do.
Gill
Oh god no. Not again. Why. Don't let him get meter or he'll come back from the dead. Banned at tournaments, but allowed to be used online? Why????